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  1. Amanda R Perry

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0001474



How to Cite

Perry, A. R. 2001. Oncogenes. eLS. .

Author Information

  1. Institute of Cancer Research, Sutton, Surrey, UK

Publication History

  1. Published Online: 19 APR 2001


Oncogenes are the activated forms of normal cellular genes whose protein products are involved in key signalling pathways governing cell survival, proliferation and differentiation. Through a variety of mechanisms, including viral infection and chemical-induced mutation, these proteins become hyperactive or overexpressed and contribute to the cell growth and behaviour typical of cancer cells.


  • oncogene;
  • proto-oncogene;
  • oncoprotein;
  • retrovirus;
  • mutation;
  • signal transduction;
  • signalling pathway;
  • cell cycle;
  • transformation;
  • cancer