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Oncogenes

  1. Amanda R Perry

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0001474

eLS

eLS

How to Cite

Perry, A. R. 2001. Oncogenes. eLS. .

Author Information

  1. Institute of Cancer Research, Sutton, Surrey, UK

Publication History

  1. Published Online: 19 APR 2001
Table 1. Examples of retroviral oncogenes and their cellular homologues
RetrovirusViral oncogeneCellular homologue
Abelson murine leukaemia virusablABL
Avian erythroblastosis viruserbA, erbB, etsERBA, ERBB (EGFR), ETS
FBJ murine osteosarcoma virusfosFOS
Avian sarcoma virus-17junJUN
Avian myelocytomatosis virusmycMYC
Murine sarcoma virusH-ras, K-rasH-RAS, K-RAS
Rous sarcoma virussrcSRC
Table 2. Mechanisms of cellular oncogene activation
MalignancyOncogeneMutation
GlioblastomaEGFRAmplification
Breast carcinomaERB-B2Amplification
Breast carcinomaCCND1Amplification
NeuroblastomaERB-B2Point mutation
Pancreatic carcinomaRASPoint mutation
Colorectal carcinomaRASPoint mutation
Chronic myeloid leukaemiaBCR-ABLGene fusion
Burkitt lymphomaMYCIgH juxtaposition
Follicular lymphomaBCL2IgH juxtaposition
Mantle cell lymphomaCCND1IgH juxtaposition