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Transfer RNA in Decoding and the Wobble Hypothesis

  1. Mick F Tuite

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0001497

eLS

eLS

How to Cite

Tuite, M. F. 2001. Transfer RNA in Decoding and the Wobble Hypothesis. eLS. .

Author Information

  1. University of Kent, Canterbury, Kent, UK

Publication History

  1. Published Online: 19 APR 2001

Abstract

The translation of the genetic code stored in messenger RNA requires significantly fewer tranfer RNAs than there are codons. This is achieved through an increased flexibility in the allowable base-pair interactions between the mRNA and tRNA involving the third position of the codon. The rules governing the allowable base-pair interactions were originally summarized in Crick's ‘wobble hypothesis’.

Keywords:

  • wobble hypothesis;
  • tRNA;
  • mRNA decoding;
  • codon recognition