Transfer RNA in Decoding and the Wobble Hypothesis
Published Online: 19 APR 2001
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Tuite, M. F. 2001. Transfer RNA in Decoding and the Wobble Hypothesis. eLS. .
- Published Online: 19 APR 2001
The translation of the genetic code stored in messenger RNA requires significantly fewer tranfer RNAs than there are codons. This is achieved through an increased flexibility in the allowable base-pair interactions between the mRNA and tRNA involving the third position of the codon. The rules governing the allowable base-pair interactions were originally summarized in Crick's ‘wobble hypothesis’.
- wobble hypothesis;
- mRNA decoding;
- codon recognition