Standard Article

Site-specific Recombination in Chromosome Function

  1. David J Sherratt

Published Online: 25 APR 2001

DOI: 10.1038/npg.els.0001499



How to Cite

Sherratt, D. J. 2001. Site-specific Recombination in Chromosome Function. eLS. .

Author Information

  1. University of Oxford, Oxford, UK

Publication History

  1. Published Online: 25 APR 2001


Site-specific recombination leads to the integration, deletion or inversion of defined DNA segments by conservative breakage–rejoining reactions at defined recombination sites. It functions to integrate and excise extrachromosomal elements into and out of genomes, to maintain circular replicons at the correct copy number in a monomeric state, and to mediate inversion gene switches.


  • site-specific recombination;
  • resolvase;
  • invertase;
  • integrase