Standard Article

Duchenne Muscular Dystrophy

  1. Marek Michalak1,
  2. Michal Opas2

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0002008

eLS

eLS

How to Cite

Michalak, M. and Opas, M. 2001. Duchenne Muscular Dystrophy. eLS. .

Author Information

  1. 1

    University of Alberta, Edmonton, Alberta, Canada

  2. 2

    University of Toronto, Toronto, Ontario, Canada

Publication History

  1. Published Online: 19 APR 2001

Abstract

Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder that affects muscles and causes progressive weakness. Dystrophin, the product of the DMD gene, is one of several membrane proteins that form the dystrophin–glycoprotein complex, which helps to maintain the integrity of muscle cells; loss of these proteins leads to the wasting of muscle cells and to the pathology of DMD.

Keywords:

  • dystrophin;
  • muscular dystrophies;
  • dystroglycan;
  • sarcoglycan;
  • muscle pathology