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Rhesus Haemolytic Disease of the Newborn

  1. Elizabeth A Letsky

Published Online: 25 APR 2001

DOI: 10.1038/npg.els.0002290



How to Cite

Letsky, E. A. 2001. Rhesus Haemolytic Disease of the Newborn. eLS. .

Author Information

  1. Queen Charlotte's and Chelsea Hospital, London, UK

Publication History

  1. Published Online: 25 APR 2001


Rhesus (Rh) haemolytic disease of the newborn arises from maternal anti-D immunoglobulin (Ig) G antibodies which cross the placenta and are directed against paternally derived D antigens which the fetus carries and the mother lacks. Untreated, this condition can result in intrauterine death from anaemia and cardiac failure (hydrops) or neonatal neurological problems and death following the development of severe jaundice and kernicterus.


  • Rh alloimmunization;
  • anti-D prophylaxis;
  • hydrops;
  • in-utero transfusion;
  • kernicterus