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Selection and Common Monogenic Disease

  1. John Clegg

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0002294



How to Cite

Clegg, J. 2001. Selection and Common Monogenic Disease. eLS. .

Author Information

  1. University of Oxford, Oxford, UK

Publication History

  1. Published Online: 19 APR 2001


Major environmental changes following the development of agriculture have had a profound effect on the human gene pool by means of adaptive responses to new ecological relationships. The frequent occurrence of serious inherited red cell diseases in many parts of the world as a direct result of chronic exposure to malaria is an example that probably has many parallels with other genetic and infectious diseases.


  • haemoglobin;
  • thalassaemia;
  • malaria;
  • infectious disease