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Signal Transduction Pathways in Development: Hedgehog Proteins and their Receptors

  1. Marcel van den Heuvel

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0002329

eLS

eLS

How to Cite

van den Heuvel, M. 2001. Signal Transduction Pathways in Development: Hedgehog Proteins and their Receptors. eLS. .

Author Information

  1. MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, UK

Publication History

  1. Published Online: 19 APR 2001

Abstract

The Hedgehog proteins comprise a family of secreted signalling proteins of crucial importance for development of metazoan animals. The signalling pathway downstream of Hedgehog proteins is highly conserved in evolution. Loss or misactivation of the Hh signalling pathway can lead to pathogenesis.

Keywords:

  • hedgehog;
  • development;
  • signal transduction