Standard Article

Tumorigenicity Assays

  1. Thomas Leth Frandsen1,
  2. Claus Holst-Hansen2,
  3. Nils Brünner3

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0002608

eLS

eLS

How to Cite

Frandsen, T. L., Holst-Hansen, C. and Brünner, N. 2001. Tumorigenicity Assays. eLS. .

Author Information

  1. 1

    Copenhagen University Hospital, Copenhagen, Denmark

  2. 2

    Copenhagen University Hospital, Copenhagen, Denmark

  3. 3

    Copenhagen University Hospital, Copenhagen, Denmark

Publication History

  1. Published Online: 19 APR 2001

Abstract

Tumorigenicity is defined as the ability of cultured cells to give rise to either benign or malignant progressively growing tumours showing viable and mitotically active cells in immunologically nonresponsive animals over a limited observation period. The ability of a cell line to produce tumour in an animal is highly dependent on and defined by the assay in which it is tested. A variety of animal systems are suitable for in vivo tumorigenesis studies.

Keywords:

  • tumorigenicity;
  • invasion;
  • mice;
  • tumour cell culture