Protein Motifs: the Helix-Loop-Helix Motif
Published Online: 3 MAY 2005
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Sablitzky, F. 2005. Protein Motifs: the Helix-Loop-Helix Motif. eLS. .
- Published Online: 3 MAY 2005
The helix-loop-helix (HLH) domain is characterized by two sets of amino acid sequences that fold into amphipathic α helices separated by a flexible linker or ‘loop’ of variable amino acid sequence and length. The HLH domain is a dimerization domain that allows proteins to form homo- and/or heterodimers.
- homo- and heterodimers;
- basic DNA-binding domain;
- e box;
- leucine zipper;
- PAS domain