X-ray Diffraction: Principles
Published Online: 28 MAY 2003
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Drenth, J. 2003. X-ray Diffraction: Principles. eLS. .
- Published Online: 28 MAY 2003
The properties of biological macromolecules cannot be fully understood without knowledge of their three-dimensional structure. For mutation of proteins and for rational drug design it is essential to know the three-dimensional structure. X-ray diffraction is one technique for structure determination. It requires the macromolecules to be present in a well-organized arrangement as crystals or as fibres; amorphous material does not provide sufficient information.