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DNA Structure: Sequence Effects

  1. Maxim D Frank-Kamenetskii

Published Online: 4 MAY 2005

DOI: 10.1038/npg.els.0002976



How to Cite

Frank-Kamenetskii, M. D. 2005. DNA Structure: Sequence Effects. eLS. .

Author Information

  1. Boston University, Boston, Massachusetts, USA

Publication History

  1. Published Online: 4 MAY 2005

This is not the most recent version of the article. View current version (17 MAR 2014)


DNA sequence significantly affects the local stability of the DNA double helix. In addition, depending on their particular sequence, different DNA sites are capable of adopting various unusual structures.


  • kinetic stability;
  • thermodynamic stability;
  • DNA melting;
  • supercoiling;
  • Gibbs free energy;
  • DNA unusual structures