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Amino Acid Side-chain Hydrophobicity

  1. Hue Sun Chan

Published Online: 22 MAR 2002

DOI: 10.1038/npg.els.0003005



How to Cite

Chan, H. S. 2002. Amino Acid Side-chain Hydrophobicity. eLS. .

Author Information

  1. University of Toronto, Toronto, Canada

Publication History

  1. Published Online: 22 MAR 2002


Hydrophobicity is the unfavourable energetics of dissolving nonpolar compounds in water. The hydrophobicities of the 20 amino acid side-chains are currently described by hydrophobicity scales derived primarily from solubility studies; these scales have provided semiquantitative rationalizations of some properties of native (folded) proteins.


  • model compounds;
  • solvation;
  • statistical potentials