Standard Article

Protein Structural Flexibility: Molecular Motions

  1. Richard H Henchman1,
  2. J Andrew McCammon2

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0003012

eLS

eLS

How to Cite

Henchman, R. H. and McCammon, J. A. 2005. Protein Structural Flexibility: Molecular Motions. eLS. .

Author Information

  1. 1

    School of Chemistry, University of Manchester, UK

  2. 2

    Howard Hughes Medical Institute, University of California at SanDiego, USA

Publication History

  1. Published Online: 23 SEP 2005

Abstract

Protein molecules are intrinsically flexible and typically undergo a wide variety of motions at normal temperatures. The flexibility and dynamics of proteins have been harnessed by evolution for a wide variety of their activities, ranging from ligand binding to regulation of function.

Keywords:

  • protein dynamics;
  • enzyme mechanisms;
  • allostery