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Protein Folding: Overview of Pathways

  1. William J Wedemeyer,
  2. Harold A Scheraga

Published Online: 25 APR 2001

DOI: 10.1038/npg.els.0003016



How to Cite

Wedemeyer, W. J. and Scheraga, H. A. 2001. Protein Folding: Overview of Pathways. eLS. .

Author Information

  1. Cornell University, Ithaca, New York, USA

Publication History

  1. Published Online: 25 APR 2001


Most proteins can function only if they are folded – i.e. if they have adopted a specific, stable tertiary structure. The ‘protein folding problem’ is to determine how and why the initially unstructured protein converges to this native structure. A typical sequence of structural changes during the folding of a protein molecule is referred to as a folding pathway.


  • protein folding;
  • folding pathways;
  • nucleation;
  • hydrophobic collapse;
  • kinetic models