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Time-resolved X-ray Crystallography

  1. Barry L Stoddard

Published Online: 22 MAR 2002

DOI: 10.1038/npg.els.0003046

eLS

eLS

How to Cite

Stoddard, B. L. 2002. Time-resolved X-ray Crystallography. eLS. .

Author Information

  1. Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Publication History

  1. Published Online: 22 MAR 2002

Abstract

Time-resolved crystallography is a collection of methods whereby biological reactions proceed in crystals of a macromolecular catalyst, and structures of intermediates formed on the reaction pathway are determined using X-ray crystallography. Such experiments allow investigators to visualize directly the mechanism of enzyme-catalysed reactions or other biological processes.

Keywords:

  • laue diffraction;
  • trapping;
  • enzyme mechanism;
  • photocage;
  • crystallography