Standard Article

NAD(P)+ Binding to Dehydrogenases

  1. Henry Weiner1,
  2. Thomas D Hurley2

Published Online: 3 MAY 2005

DOI: 10.1038/npg.els.0003049



How to Cite

Weiner, H. and Hurley, T. D. 2005. NAD(P)+ Binding to Dehydrogenases. eLS. .

Author Information

  1. 1

    Purdue University, West Lafayette, Indiana, USA

  2. 2

    Indiana University School of Medicine, Indianapolis, Indiana, USA

Publication History

  1. Published Online: 3 MAY 2005


Each NAD-dependent dehydrogenase binds its coenzyme in a unique manner. Virtually all possess a highly conserved binding domain called the Rossmann fold that is involved in this interaction and dictates the specificity of hydride transfer.


  • NAD+;
  • NADP+;
  • dehydrogenases;
  • rossmann fold;
  • coenzyme;
  • redox reactions