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Mass Spectrometry: Peptide Sequencing

  1. J Throck Watson

Published Online: 25 APR 2001

DOI: 10.1038/npg.els.0003111



How to Cite

Watson, J. T. 2001. Mass Spectrometry: Peptide Sequencing. eLS. .

Author Information

  1. Michigan State University, East Lansing, Michigan, USA

Publication History

  1. Published Online: 25 APR 2001


Electrospray and MALDI (matrix-assisted laser desorption ionization) are two versions of desorption/ionization that allow modern mass spectrometry to be applied to the analysis of peptides and proteins. In addition to a direct indication of the molecular weight, the sequence of amino acids in a peptide can be deduced from the fragmentation pattern (the mass spectrum itself).


  • electrospray;
  • MALDI;
  • signal suppression;
  • mass spectrum;
  • matrix-assisted laser desorption ionization