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Protein–DNA Interactions: Techniques Used

  1. Mark A Strauch

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0003128



How to Cite

Strauch, M. A. 2001. Protein–DNA Interactions: Techniques Used. eLS. .

Author Information

  1. University of Maryland, Baltimore, Maryland, USA

Publication History

  1. Published Online: 19 APR 2001


A plethora of biochemical and biophysical techniques are used to investigate various aspects of protein–DNA interactions. Some of the more common and useful of these are filter binding, the gel mobility shift assay, a large group of related techniques broadly categorized as footprinting, high-resolution microscopy and spectroscopy.


  • protein–DNA complexes;
  • techniques;
  • DNA-binding proteins