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Hammerhead Ribozymes

  1. John R Rossi

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0003133



How to Cite

Rossi, J. R. 2001. Hammerhead Ribozymes. eLS. .

Author Information

  1. Beckman Research Institute of the City of Hope, Duarte, California, USA

Publication History

  1. Published Online: 19 APR 2001


The hammerhead ribozyme is an RNA-cleaving, RNA enzyme, derived from single-stranded RNA viroids, and virusoids, which infect flowering plants. Engineering of hammerhead ribozymes allows these RNA catalysts to be utilized for cleaving virtually any RNA target of choice, thus making them useful tools for both genetic and therapeutic applications.


  • ribonucleic acid;
  • RNA;
  • gene therapy;
  • catalysis;
  • site-specific cleavage