Standard Article

Protein–Nucleic Acid Interaction: Major Groove Recognition Determinants

  1. Yong Xiong,
  2. Muttaiya Sundaralingam

Published Online: 25 APR 2001

DOI: 10.1038/npg.els.0003138

eLS

eLS

How to Cite

Xiong, Y. and Sundaralingam, M. 2001. Protein–Nucleic Acid Interaction: Major Groove Recognition Determinants. eLS. .

Author Information

  1. Ohio State University, Columbus, Ohio, USA

Publication History

  1. Published Online: 25 APR 2001

Abstract

Protein–nucleic acid interactions play a crucial role in central biological processes. It is known that the most common binding element of proteins is an α helix and the primary binding site on DNA is in the major groove. Some general rules of the α helix binding to the DNA major groove have been derived, but there is no general code (one-to-one correspondence) for recognition.

Keywords:

  • protein–nucleic acid complexes;
  • zinc finger;
  • α helix binding;
  • major groove interactions