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Protein–Ligand Interactions: Induced Fit

  1. Buyong Ma1,
  2. Sandeep Kumar1,
  3. Chung-Jung Tsai1,
  4. Haim Wolfson2,
  5. Neeti Sinha1,
  6. Ruth Nussinov3,4

Published Online: 30 MAY 2001

DOI: 10.1038/npg.els.0003140

eLS

eLS

How to Cite

Ma, B., Kumar, S., Tsai, C.-J., Wolfson, H., Sinha, N. and Nussinov, R. 2001. Protein–Ligand Interactions: Induced Fit. eLS. .

Author Information

  1. 1

    Frederick Cancer Research and Development Center National Cancer Institute, Frederick, Maryland, USA

  2. 2

    Tel Aviv University, Tel Aviv, Israel

  3. 3

    Frederick Cancer Research and Development Center National Cancer Institute, Frederick, Maryland, USA

  4. 4

    Tel Aviv University, Tel Aviv, Israel

Publication History

  1. Published Online: 30 MAY 2001

Abstract

Protein–ligand interactions include two major components: protein folding and binding mechanisms; and hinge bending conformational transitions.

Keywords:

  • hydrophobic effect;
  • hydrogen bond;
  • shape complementarity;
  • molecular recognition;
  • receptor–ligand interactions