Chromatin Remodelling and Histone Modification in Transcription Regulation
Published Online: 25 JUL 2001
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Urnov, F. D. and Wolffe, A. P. 2001. Chromatin Remodelling and Histone Modification in Transcription Regulation. eLS. .
- Published Online: 25 JUL 2001
The eukaryotic genome is assembled into chromatin, localized alterations of which are a major feature of gene control pathways. A wide variety of dedicated enzymatic complexes are targeted by particular transcriptional regulators to specific loci in the genome and remodel the structure of chromatin via energy-dependent disruption of histone–DNA contacts and covalent modification of histones, both with major regulatory consequences.
- chromatin remodelling;
- histone deacetylase;
- histone acetyltransferase