Standard Article

Chromatin Remodelling and Histone Modification in Transcription Regulation

  1. Fyodor D Urnov,
  2. Alan P Wolffe

Published Online: 25 JUL 2001

DOI: 10.1038/npg.els.0003304

eLS

eLS

How to Cite

Urnov, F. D. and Wolffe, A. P. 2001. Chromatin Remodelling and Histone Modification in Transcription Regulation. eLS. .

Author Information

  1. Sangamo Biosciences, Richmond, California, USA

Publication History

  1. Published Online: 25 JUL 2001

Abstract

The eukaryotic genome is assembled into chromatin, localized alterations of which are a major feature of gene control pathways. A wide variety of dedicated enzymatic complexes are targeted by particular transcriptional regulators to specific loci in the genome and remodel the structure of chromatin via energy-dependent disruption of histone–DNA contacts and covalent modification of histones, both with major regulatory consequences.

Keywords:

  • transcription;
  • nucleosome;
  • chromatin remodelling;
  • histone deacetylase;
  • histone acetyltransferase