Published Online: 3 MAY 2005
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Wishart, M. J. and Guan, K.-L. 2005. Protein Phosphatases. eLS.
- Published Online: 3 MAY 2005
Eukaryotic protein phosphatases are generally classified according to substrate specificity and three-dimensional structure into two large groups: protein serine/threonine phosphatases, metalloproteins that dephosphorylate substrates via a single-step reaction involving a metal-activated water molecule, and protein tyrosine phosphatases, which contain an active-site cysteine thiolate that forms a phosphoenzyme intermediate prior to nucleophilic breakdown by an activated water.