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Enzymes: Phosphopantetheine-dependent

  1. Matthew P Crump,
  2. Peter M Shoolingin-Jordan

Published Online: 22 MAR 2002

DOI: 10.1038/npg.els.0003742



How to Cite

Crump, M. P. and Shoolingin-Jordan, P. M. 2002. Enzymes: Phosphopantetheine-dependent. eLS. .

Author Information

  1. University of Southampton, Southampton, UK

Publication History

  1. Published Online: 22 MAR 2002


Phosphopantetheine-dependent enzymes are a group of multifunctional or individual enzymes including fatty acid synthases, polyketide synthases and nonribosomal polypeptide synthases, all of which utilize the 4′-phosphopantetheine moiety attached to an acyl carrier protein or a peptide carrier protein. The terminal thiol group of 4′-phosphopantetheine is covalently attached to any of a number of acyl groups in the form of a thiol ester to facilitate acyl transfer and nucleophilic activation.


  • 4′-phosphopentetheine;
  • coenzyme A (CoA);
  • thiol ester;
  • C–C bond formation;
  • acyl carrier protein;
  • fatty acid synthase;
  • nonribosomal polypeptide synthase;
  • polypeptide carrier protein;
  • antibiotic biosynthesis