Published Online: 22 MAR 2002
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Crump, M. P. and Shoolingin-Jordan, P. M. 2002. Enzymes: Phosphopantetheine-dependent. eLS.
- Published Online: 22 MAR 2002
Phosphopantetheine-dependent enzymes are a group of multifunctional or individual enzymes including fatty acid synthases, polyketide synthases and nonribosomal polypeptide synthases, all of which utilize the 4′-phosphopantetheine moiety attached to an acyl carrier protein or a peptide carrier protein. The terminal thiol group of 4′-phosphopantetheine is covalently attached to any of a number of acyl groups in the form of a thiol ester to facilitate acyl transfer and nucleophilic activation.
- coenzyme A (CoA);
- thiol ester;
- C–C bond formation;
- acyl carrier protein;
- fatty acid synthase;
- nonribosomal polypeptide synthase;
- polypeptide carrier protein;
- antibiotic biosynthesis