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Base Excision Repair, AP Endonucleases and DNA Glycosylases

  1. Miriam Sander1,
  2. Samuel H Wilson2

Published Online: 3 MAY 2005

DOI: 10.1038/npg.els.0003871

eLS

eLS

How to Cite

Sander, M. and Wilson, S. H. 2005. Base Excision Repair, AP Endonucleases and DNA Glycosylases. eLS. .

Author Information

  1. 1

    Page One Editorial Services, Durham, North Carolina, USA

  2. 2

    National Institute of Environmental Health Sciences, National Institutes of Health, North Carolina, USA

Publication History

  1. Published Online: 3 MAY 2005

Abstract

Base excision repair is an important cellular mechanism that protects the integrity of DNA by repairing damage caused by alkylating agents and reactive oxygen species. The altered DNA base, and in some cases a few nucleotides adjacent to the altered base, is removed by excision, and the DNA is repaired by DNA synthesis and ligation.

Keywords:

  • DNA repair;
  • DNA damage;
  • mutation;
  • polymerase;
  • nuclease