Standard Article

Glycolysis Regulation

  1. Gary D Lopaschuk,
  2. Jason RB Dyck

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0003882



How to Cite

Lopaschuk, G. D. and Dyck, J. R. 2005. Glycolysis Regulation. eLS. .

Author Information

  1. University of Alberta, Edmonton, Alberta, Canada

Publication History

  1. Published Online: 23 SEP 2005


Glycolysis provides an important source of energy for most cells as well as a source of substrate for a number of other metabolic pathways. Its regulation is complex, involving allosteric control, phosphorylation control and transcriptional control of glycolytic enzymes. Modulation of fructose 2,6-bisphosphate has emerged as one of the key sites at which glycolysis is controlled.


  • hexokinase;
  • phosphofructokinase;
  • glyceraldehyde-3-phosphate dehydrogenase;
  • Pasteur effect;
  • substrate cycles