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Iron Cofactors: Nonhaem

  1. Brian G Fox

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0003888



How to Cite

Fox, B. G. 2005. Iron Cofactors: Nonhaem. eLS. .

Author Information

  1. University of Wisconsin, Madison, Wisconsin, USA

Publication History

  1. Published Online: 23 SEP 2005

This is not the most recent version of the article. View current version (15 OCT 2015)


Proteins and enzymes with nonhaem iron centres display many functions: metal centres with primarily sulfur ligation are involved in electron transfer, electrophilic activation of hydroxyl groups, regulation of gene expression and fixation of N2; mononuclear and diiron centres with oxygen and nitrogen ligation have roles in various reactions with O2 and in hydrolysis. The principles of their mechanisms of action are beginning to emerge from the considerable experimental data obtained on these proteins. Future research will attempt to extend this mechanistic understanding and to manipulate the enzymes to extend their already substantial catalytic capabilities.


  • enzyme;
  • iron;
  • mechanism;
  • structure