Standard Article

Termination of Replication in Bacteria

  1. Iain G Duggin1,
  2. Jackie A Wilce2

Published Online: 3 MAY 2005

DOI: 10.1038/npg.els.0003901



How to Cite

Duggin, I. G. and Wilce, J. A. 2005. Termination of Replication in Bacteria. eLS. .

Author Information

  1. 1

    University of Sydney, Sydney, Australia

  2. 2

    University of Western Australia, Perth, Australia

Publication History

  1. Published Online: 3 MAY 2005


In the case of a circular bacterial chromosome, termination of DNA replication occurs when the two replication forks, progressing in opposite directions, meet and fuse in a specific region of the chromosome, which is generally diametrically opposed to the site of initiation of DNA replication. Most research has focused on the systems utilized by the rod-shaped Gram-negative Escherichia coli and Gram-positive Bacillus subtilis.


  • DNA replication;
  • replication termination;
  • replication fork arrest;
  • DNA terminators;
  • replication terminator protein;
  • termination utilization substance;
  • catenanes