Published Online: 3 MAY 2005
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Tuchman, M. 2005. Urea Cycle. eLS.
- Published Online: 3 MAY 2005
The mammalian urea cycle, discovered by Krebs and Henseleit in 1932, takes place in the liver. It is the main chemical pathway used by ureotelic species to dispose of ammonium nitrogen by converting it into urea, which is much less toxic and efficiently excreted by the kidneys.
Keywords: urea cycle; ammonia; hyperammonaemia; amino acid; arginine