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Nucleotide Degradation

  1. Jörgen Bierau1,
  2. André BP van Kuilenburg2,
  3. Albert H van Gennip1

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0003908



How to Cite

Bierau, J., van Kuilenburg, A. B. and van Gennip, A. H. 2005. Nucleotide Degradation. eLS. .

Author Information

  1. 1

    Maastricht University Hospital, Maastricht, The Netherlands

  2. 2

    Academic Medical Center, Amsterdam, The Netherlands

Publication History

  1. Published Online: 23 SEP 2005


Nucleotide degradation is an integrated process in all human cells that is intimately linked with the pathways of nucleotide synthesis and salvage. The clinical conditions associated with defects of enzymes catalysing nucleotide degradation provide a valuable insight into the importance of this network.


  • inherited defects;
  • immunodeficiency;
  • bone marrow transplantation;
  • neurological deficits;
  • antimetabolite toxicity;
  • neurotoxicity