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Protein Kinases: Physiological Roles in Cell Signalling

  1. James Robert Woodgett,
  2. Mark Takahashi

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0003919

eLS

eLS

How to Cite

Woodgett, J. R. and Takahashi, M. 2006. Protein Kinases: Physiological Roles in Cell Signalling. eLS. .

Author Information

  1. Ontario Cancer Institute, Ontario, Canada

Publication History

  1. Published Online: 27 JAN 2006

Abstract

Protein kinases play multiple roles in cells and act as the primary messenger enzymes that coordinate cellular responses to the environment. This article discusses the different roles this class of molecules play in regulating processes such as cell death and proliferation as well as the disease consequences of their dysregulation.

Keywords:

  • protein phosphorylation;
  • apoptosis;
  • gene expression;
  • transcription;
  • disease