Published Online: 27 JAN 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Kisliuk, R. 2006. Thymidylate Synthesis. eLS. .
- Published Online: 27 JAN 2006
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Thymidylate, an essential component of DNA, is synthesized from deoxyuridylate and methylenetetrahydrofolate by thymidylate synthase, but dihydrofolate reductase and serine hydroxymethyltransferase are required to regenerate methylenetetrahydrofolate. Inhibitors of the synthase and the reductase arrest cell replication and are used in the treatment of cancer.