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RecA Protein

  1. Piero R Bianco,
  2. Stephen C Kowalczykowski

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0003925



How to Cite

Bianco, P. R. and Kowalczykowski, S. C. 2005. RecA Protein. eLS. .

Author Information

  1. University of California, Davis, California, USA

Publication History

  1. Published Online: 23 SEP 2005


The RecA protein of Escherichia coli is the prototypic deoxyribonucleic acid (DNA) strand exchange protein. It assembles on single-stranded DNA to form a helical nucleoprotein filament that is the active species for all RecA protein-dependent functions. This protein–DNA complex is responsible for three mutually exclusive functions: DNA recombination, induction of the DNA-damage SOS response and SOS-induced mutagenesis.


  • DNA strand exchange;
  • genetic recombination;
  • SOS response;
  • SOS mutagenesis;
  • nucleoprotein filament;
  • LexA repressor