Transfer RNA Synthetase Editing of Amino Acids
Published Online: 3 MAY 2005
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Jakubowski, H. 2005. Transfer RNA Synthetase Editing of Amino Acids. eLS. .
- Published Online: 3 MAY 2005
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Intrinsic binding energies of amino acids to aminoacyl-tRNA synthetases are often inadequate to give the required accuracy of translation. This has necessitated the evolution of a second determinant of specificity, proofreading or editing mechanisms that remove errors in amino acid selection and prevent access of nonprotein amino acids to the genetic code. Editing of homocysteine and ornithine is linked to human disease.
- genetic code;
- protein biosynthesis;
- protein engineering;
- amino acid editing;
- non-protein amino acids;
- aminoacyl-coenzyme A thioesters