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Pyruvate Dehydrogenase Complex

  1. Mulchand S Patel,
  2. Lioubov G Korotchkina

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0003943

eLS

eLS

How to Cite

Patel, M. S. and Korotchkina, L. G. 2006. Pyruvate Dehydrogenase Complex. eLS.

Author Information

  1. State University of New York at Buffalo, Buffalo, New York, USA

Publication History

  1. Published Online: 27 JAN 2006

Abstract

Pyruvate dehydrogenase complex (PDC) is a highly organized multienzyme complex that plays a key role in glucose metabolism providing a direct link between glycolysis and the tricarboxylic acid cycle. PDC is tightly regulated according to changing demands in glucose consumption in different tissues and under different nutritional and pathophysiological conditions.

Keywords:

  • pyruvate dehydrogenase;
  • regulation by phosphorylation/dephosphorylation;
  • genetic defects;
  • pyruvate dehydrogenase deficiency;
  • glucose metabolism