Standard Article

Pyruvate Dehydrogenase Complex

  1. Mulchand S Patel,
  2. Lioubov G Korotchkina

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0003943



How to Cite

Patel, M. S. and Korotchkina, L. G. 2006. Pyruvate Dehydrogenase Complex. eLS. .

Author Information

  1. State University of New York at Buffalo, Buffalo, New York, USA

Publication History

  1. Published Online: 27 JAN 2006


Pyruvate dehydrogenase complex (PDC) is a highly organized multienzyme complex that plays a key role in glucose metabolism providing a direct link between glycolysis and the tricarboxylic acid cycle. PDC is tightly regulated according to changing demands in glucose consumption in different tissues and under different nutritional and pathophysiological conditions.


  • pyruvate dehydrogenase;
  • regulation by phosphorylation/dephosphorylation;
  • genetic defects;
  • pyruvate dehydrogenase deficiency;
  • glucose metabolism