Pyruvate Dehydrogenase Complex
Published Online: 27 JAN 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Patel, M. S. and Korotchkina, L. G. 2006. Pyruvate Dehydrogenase Complex. eLS.
- Published Online: 27 JAN 2006
Pyruvate dehydrogenase complex (PDC) is a highly organized multienzyme complex that plays a key role in glucose metabolism providing a direct link between glycolysis and the tricarboxylic acid cycle. PDC is tightly regulated according to changing demands in glucose consumption in different tissues and under different nutritional and pathophysiological conditions.
- pyruvate dehydrogenase;
- regulation by phosphorylation/dephosphorylation;
- genetic defects;
- pyruvate dehydrogenase deficiency;
- glucose metabolism