Standard Article

Peptide Chain Elongation: Models of the Elongation Cycle

  1. Knud H Nierhaus,
  2. Daniel N Wilson

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0003949

eLS

eLS

How to Cite

Nierhaus, K. H. and Wilson, D. N. 2006. Peptide Chain Elongation: Models of the Elongation Cycle. eLS. .

Author Information

  1. Max-Planck Institute for Molecular Genetics, Berlin, Germany

Publication History

  1. Published Online: 27 JAN 2006

Abstract

Three models of the ribosomal elongation cycle are used to explain the mechanism of protein synthesis on the ribosome. These are the allosteric three-site model, the hybrid site model and the α–ε model. Recent cryoelectron microscopy analyses significantly modify the current models.

Keywords:

  • protein synthesis;
  • ribosome;
  • translocation of tRNAs