Gene Expression: Decoding and Accuracy of Translation
Published Online: 27 JAN 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Nierhaus, K. H. 2006. Gene Expression: Decoding and Accuracy of Translation. eLS. .
- Published Online: 27 JAN 2006
During decoding of the genetic message, the ribosome must select the correct substrate, a ternary complex aminoacyl-tRNA–EF-Tu–GTP, from a large number of almost identical complexes. The problem is solved by dividing substrate binding into two steps: (1) decoding, which is mainly restricted to codon–anticodon interactions, and (2) interactions between substrate and ribosome, which are mainly responsible for high-affinity binding rather than for selectivity.
- protein synthesis;
- molecular recognition;