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Gene Expression: Decoding and Accuracy of Translation

  1. Knud H Nierhaus

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0003950



How to Cite

Nierhaus, K. H. 2006. Gene Expression: Decoding and Accuracy of Translation. eLS. .

Author Information

  1. Max-Planck Institute for Molecular Genetics, Berlin, Germany

Publication History

  1. Published Online: 27 JAN 2006


During decoding of the genetic message, the ribosome must select the correct substrate, a ternary complex aminoacyl-tRNA–EF-Tu–GTP, from a large number of almost identical complexes. The problem is solved by dividing substrate binding into two steps: (1) decoding, which is mainly restricted to codon–anticodon interactions, and (2) interactions between substrate and ribosome, which are mainly responsible for high-affinity binding rather than for selectivity.


  • translation;
  • protein synthesis;
  • accuracy;
  • decoding;
  • molecular recognition;
  • processivity;
  • proofreading;
  • frameshift