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Peptidyl Transfer on the Ribosome

  1. Knud H Nierhaus,
  2. Daniel N Wilson

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0003951



How to Cite

Nierhaus, K. H. and Wilson, D. N. 2006. Peptidyl Transfer on the Ribosome. eLS. .

Author Information

  1. Max-Planck Institute for Molecular Genetics, Berlin, Germany

Publication History

  1. Published Online: 27 JAN 2006


Formation of the peptide bond is the central enzymatic activity of ribosomes. The active centre resides on the large ribosomal subunit, and is made of nucleotides from domain V of the 23S-type rRNA.


  • peptidyltransferase;
  • rRNA, function in peptide-bond formation;
  • enzyme mechanism, template model;
  • enzyme mechanism, chemical catalysis