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Peptidyl Transfer on the Ribosome

  1. Knud H Nierhaus,
  2. Daniel N Wilson

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0003951

eLS

eLS

How to Cite

Nierhaus, K. H. and Wilson, D. N. 2006. Peptidyl Transfer on the Ribosome. eLS. .

Author Information

  1. Max-Planck Institute for Molecular Genetics, Berlin, Germany

Publication History

  1. Published Online: 27 JAN 2006

Abstract

Formation of the peptide bond is the central enzymatic activity of ribosomes. The active centre resides on the large ribosomal subunit, and is made of nucleotides from domain V of the 23S-type rRNA.

Keywords:

  • peptidyltransferase;
  • rRNA, function in peptide-bond formation;
  • enzyme mechanism, template model;
  • enzyme mechanism, chemical catalysis