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Immunological Synapse

  1. Salvatore Valitutti,
  2. Nicolas Espagnolle

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0004027



How to Cite

Valitutti, S. and Espagnolle, N. 2006. Immunological Synapse. eLS. .

Author Information

  1. Institut National de la Santé et de la Recherche Médicale, Paris, France

Publication History

  1. Published Online: 27 JAN 2006


The immunological synapse is a specialized signalling domain formed at the contact site between cells of the immune system characterized by large-scale clustering and segregation of surface molecules and intracellular signalling components. The molecular dynamics taking place at the immunological synapse is the manifestation of a sustained and elaborate cell–cell information transfer.


  • immunological synapses;
  • T-cell antigen receptor;
  • signal transduction;
  • T-lymphocyte activation;
  • antigen recognition