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Axonal Transport and the Neuronal Cytoskeleton

  1. PW Baas1,
  2. A Karabay2

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0004050

eLS

eLS

How to Cite

Baas, P. and Karabay, A. 2005. Axonal Transport and the Neuronal Cytoskeleton. eLS. .

Author Information

  1. 1

    Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

  2. 2

    Istanbul Technical University, Istanbul, Turkey

Publication History

  1. Published Online: 23 SEP 2005

Abstract

The neuronal cytoskeleton is a system of highly organized polymers that provide architectural support for axons and dendrites, and also provide railways for the transport of various classes of cytoplasmic constituents. Molecular motor proteins use the energy derived from adenosine triphosphate hydrolysis for the transport of organelles along the cytoskeletal polymers and for the transport of the polymers themselves. Axons can traverse exceeding long distances in the body, and hence require sophisticated mechanisms of axonal transport in both the anterograde and the retrograde direction.

Keywords:

  • axon;
  • dendrite;
  • neuron;
  • axonal transport;
  • microtubule;
  • microfilament;
  • motor protein