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Xenopus Embryo: β-catenin and Dorsal–Ventral Axis Formation

  1. Randall T Moon

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0004185

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eLS

How to Cite

Moon, R. T. 2005. Xenopus Embryo: β-catenin and Dorsal–Ventral Axis Formation. eLS. .

Author Information

  1. University of Washington and Howard Hughes Medical Institute, Seattle, Washington, USA

Publication History

  1. Published Online: 23 SEP 2005

Abstract

During embryonic development of the amphibian, Xenopus laevis, the dorsal side of the embryo forms approximately opposite the sperm entry point, and the anterior and posterior axes are linked to this through the process of gastrulation. The mechanisms responsible for specification of the dorsal axis include a post-fertilization cortical rotation that promotes a dorsal accumulation of β-catenin, and the activation of a cascade of regulatory genes by the complexes of β-catenin and HMG box transcription factors that start the process of gastrulation.

Keywords:

  • Xenopus;
  • embryo;
  • gene expression;
  • axis;
  • β-catenin