Standard Article

Signal Transduction Pathways in Development: the JAK/STAT Pathway

  1. Tetsuji Naka,
  2. Tomoharu Ohkawara

Published Online: 24 APR 2006

DOI: 10.1038/npg.els.0004188

eLS

eLS

How to Cite

Naka, T. and Ohkawara, T. 2006. Signal Transduction Pathways in Development: the JAK/STAT Pathway. eLS. .

Author Information

  1. Osaka University Graduate School of Medicine, Osaka, Japan

Publication History

  1. Published Online: 24 APR 2006

Abstract

The Janus Kinase (JAK)/signal transducer and achivator of transcription (STAT) pathway is activated not only by various cytokines such as interferon and interleukin, but also by many growth factors. This pathway plays a crucial role in the signal transduction of these factors.

Keywords:

  • Cytokine;
  • JAK;
  • STAT;
  • SOCS;
  • PIAS;
  • PTP