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Caenorhabditis elegans Vulval Induction

  1. Paul W Sternberg

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0004190



How to Cite

Sternberg, P. W. 2006. Caenorhabditis elegans Vulval Induction. eLS. .

Author Information

  1. California Institute of Technology, Pasadena, California, USA

Publication History

  1. Published Online: 27 JAN 2006


Study of Caenorhabditis elegans vulval development has improved our understanding of inductive signalling and pattern formation at the single cell level, and has led to the definition of signalling cascades. Studies of signal transduction during vulval development have led to the discovery of what is considered a universal signalling pathway from growth factor receptor to RAS to MAP kinase to the nucleus, and the discovery of the LIN-12/Notch family of receptors that mediate lateral signalling.


  • intercellular signalling;
  • signal transduction;
  • pattern formation;
  • organogenesis;
  • cell lineage