Standard Article

Leucine Zippers

  1. Toshio Hakoshima

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0005049



How to Cite

Hakoshima, T. 2005. Leucine Zippers. eLS. .

Author Information

  1. Nara Institute of Science and Technology, Nara, Japan

Publication History

  1. Published Online: 23 SEP 2005

This is not the most recent version of the article. View current version (15 APR 2014)


The leucine zipper (ZIP) motif consists of a periodic repetition of a leucine residue at every seventh position and forms an α-helical conformation, which facilitates dimerization and in some cases higher oligomerization of proteins. In many eukaryotic gene regulatory proteins, the ZIP motif is flanked at its N-terminus by a basic region containing characteristic residues that facilitate DNA binding.


  • ZIP;
  • dimerization;
  • coiled coil;
  • bZIP;
  • transcription factors