Published Online: 23 SEP 2005
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Hakoshima, T. 2005. Leucine Zippers. eLS. .
- Published Online: 23 SEP 2005
This is not the most recent version of the article. View current version (15 APR 2014)
The leucine zipper (ZIP) motif consists of a periodic repetition of a leucine residue at every seventh position and forms an α-helical conformation, which facilitates dimerization and in some cases higher oligomerization of proteins. In many eukaryotic gene regulatory proteins, the ZIP motif is flanked at its N-terminus by a basic region containing characteristic residues that facilitate DNA binding.
- coiled coil;
- transcription factors