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Transmembrane Domains

  1. T Ramasarma,
  2. NV Joshi

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0005051



How to Cite

Ramasarma, T. and Joshi, N. 2005. Transmembrane Domains. eLS. .

Author Information

  1. Indian Institute of Science, Bangalore, India

Publication History

  1. Published Online: 23 SEP 2005

This is not the most recent version of the article. View current version (16 APR 2012)


One or more passes of polypeptide chains of the lipid bilayer, each consisting of about 25 hydrophobic residues with the occasional presence of a polar residue, anchor integral proteins in the cell membrane. These are known as transmembrane domains and participate in the functions of these proteins in some unspecified way. Encoded by a random exon make-up, sequences of these short stretches are highly variable with hardly any repetition.


  • transmembrane domains;
  • membrane anchors;
  • hydropathy;
  • exon distribution;
  • XTX/XCX-enriched exons