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Forkhead Domains

  1. Eckhard Kaufmann,
  2. Walter Knöchel

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0005052



How to Cite

Kaufmann, E. and Knöchel, W. 2005. Forkhead Domains. eLS. .

Author Information

  1. University of Ulm, Ulm, Germany

Publication History

  1. Published Online: 23 SEP 2005


The forkhead domain or box represents an evolutionarily conserved DNA-binding motif of winged helix structure that has a degree of similarity to the helix–turn–helix motif found in other DNA-binding proteins. Forkhead box (Fox) proteins are involved in a variety of biological processes such as early embryogenesis, organogenesis, tumorigenesis and signal transduction.


  • transcription factors;
  • gene regulation;
  • DNA–protein interaction;
  • embryogenesis;
  • signal transduction;
  • tumorigenesis