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DNA Polymerases: Eukaryotic

  1. Ulrich Hübscher

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0005058



How to Cite

Hübscher, U. 2005. DNA Polymerases: Eukaryotic. eLS. .

Author Information

  1. University of Zürich, Zürich, Switzerland

Publication History

  1. Published Online: 23 SEP 2005


Deoxyribonucleic acid (DNA) polymerases are enzymes that can use the four bases A, T, G and C to synthesize DNA according to the Watson–Crick base-pair rule (A to T and G to C). They require a template DNA and a nucleic acid (ribonucleic acid or DNA) for initiation of DNA synthesis and use the energy of the four deoxyribonucleoside 5′ triphosphates to incorporate deoxyribonucleoside 5′ monophosphates onto the template DNA.


  • DNA polymerases;
  • DNA replication;
  • DNA repair mechanisms;
  • translesion DNA synthesis;
  • cell-cycle and checkpoint functions