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DNA Polymerases: Eukaryotic

  1. Ulrich Hübscher

Published Online: 23 SEP 2005

DOI: 10.1038/npg.els.0005058

eLS

eLS

How to Cite

Hübscher, U. 2005. DNA Polymerases: Eukaryotic. eLS. .

Author Information

  1. University of Zürich, Zürich, Switzerland

Publication History

  1. Published Online: 23 SEP 2005

Abstract

Deoxyribonucleic acid (DNA) polymerases are enzymes that can use the four bases A, T, G and C to synthesize DNA according to the Watson–Crick base-pair rule (A to T and G to C). They require a template DNA and a nucleic acid (ribonucleic acid or DNA) for initiation of DNA synthesis and use the energy of the four deoxyribonucleoside 5′ triphosphates to incorporate deoxyribonucleoside 5′ monophosphates onto the template DNA.

Keywords:

  • DNA polymerases;
  • DNA replication;
  • DNA repair mechanisms;
  • translesion DNA synthesis;
  • cell-cycle and checkpoint functions